Syndromes of hematophagocytosis in patients of pediatric intensive care units (literature review)

Hemophagocytic lymphohistiocytosis (hemophagocytic syndrome, HLH, HPS) is the group of severe life-threatening and hardly diagnosing conditions caused by immune dysregulation because systemic inflammatory response with non-controlled proliferation activation T-cells, monocytes macrophages accumulation in target organs development multiple organ failure. HLH are includes primary (monogenic) secondary forms associated various conditions, such as infections, immunopathological, oncohematological diseases. The severity condition, association infections makes these diseases potentially lethal requiring intensive care. In many critically ill patients care unit, presence hemophagocytic syndrome remains unrecognized often interpreted generalized infection, sepsis, Such require special attention, timely diagnosis treatment. Nowadays, we have got a big drugs, which can pointwise block one or another pathogenesis pathway, but for quick correct choice, need clear algorithms deciding on use this targeted therapy. article presents history study issue modern approaches to treatment patients.